Enzymatic activity mastered by altering metal coordination spheres
نویسندگان
چکیده
منابع مشابه
Inverse tuning of metal binding affinity and protein stability by altering charged coordination residues in designed calcium binding proteins
Ca(2+ )binding proteins are essential for regulating the role of Ca(2+ )in cell signaling and maintaining Ca(2+ )homeostasis. Negatively charged residues such as Asp and Glu are often found in Ca(2+ )binding proteins and are known to influence Ca(2+ )binding affinity and protein stability. In this paper, we report a systematic investigation of the role of local charge number and type of coordin...
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ژورنال
عنوان ژورنال: JBIC Journal of Biological Inorganic Chemistry
سال: 2008
ISSN: 0949-8257,1432-1327
DOI: 10.1007/s00775-008-0414-3